What makes one Argonaute a slicer and another one not? Human Argonaute proteins are key players in the gene regulation process known as RNA interference, RNAi. Professor Joshua-Tor's group of Cold Spring Harbor Laboratory present the structure of human Argonaute-1 and determine key mutations and other features that distinguish it from human Argonaute-2, which is also known as "slicer" for its unique ability among the human Argonautes to cut messenger RNA.
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